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Avandia - Rosiglitazone

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Generic Name : Rosiglitazone
Brand Names : Avandia

What is Avandia or Rosiglitazone?

Avandia (Rosiglitazone) is an anti-diabetic drug (thiazolidinedione-type, also called "glitazones") used with a proper diet and exercise program to control high blood sugar in patients with type 2 diabetes (non-insulin-dependent diabetes). Rosiglitazone works by helping to restore the body's proper response to insulin, thereby lowering the blood sugar. Effectively controlling high blood sugar helps prevent heart disease, strokes, kidney disease, blindness, and circulation problems, as well as sexual function problems (impotence).

Avandia (Rosiglitazone) is best used only when other medications (metformin) cannot be taken.

Indications

Avandia (Rosiglitazone) is indicated to control high blood sugar in patients with type 2 diabetes

DOSAGE

The patient should take this medicine by mouth, with or without food, usually once or twice daily, or as directed by the doctor. Dosage will be based on medical condition, response to therapy. The patient should use this medication regularly in order to get the most benefit from it. The patient should try and remember to use it at the same time(s) each day. Blood glucose levels should be monitored on regular basis.

SIDE EFFECTS

The various reported side effects of the medicine are: fast/pounding heartbeat, changes in menstrual cycles, bone fracture, dark urine, yellowing of eyes/skin, persistent nausea/vomiting, stomach/abdominal pain, vision changes (e.g., color or night vision problems).

This medication usually does not cause low blood sugar (hypoglycemia), but this effect may occur if the patient do not consume enough calories (from food, juices, fruit, etc.). The symptoms include chills, cold sweat, dizziness, drowsiness, shaking, rapid heart rate, weakness, headache, fainting, tingling of the hands or feet, or hunger. It is a good habit to carry glucose tablets or gel to treat low blood sugar

DRUG INTERACTIONS

Before using this medication, the doctor should be consulted of all prescription and nonprescription/herbal products the patient is using, especially of: other anti-diabetic medications (e.g., insulin, metformin, or sulfonylureas such as glyburide), gemfibrozil, herbal/natural products (e.g., fenugreek, ginseng, gymnema), nitrates (e.g., isosorbide dinitrate), quinolone antibiotics (e.g., ciprofloxacin).

Beta-blocker medications (e.g., metoprolol, propranolol, glaucoma eye drops such as timolol) may prevent the fast/pounding heartbeat.

OVERDOSE

If overdose is suspected, the patient should contact local poison control center or emergency room immediately. It is recommended for the patient to attend a diabetes education program to understand diabetes and all the important aspects of its treatment including meals/diet, exercise, personal hygiene, medications and getting regular eye, foot and medical exams.

Lifestyle changes that help promote healthy bones include increasing weight-bearing exercise, eating well-balanced meals containing adequate calcium and vitamin D, stopping smoking, and limiting alcohol. The doctor should be consulted to see if the patient needs to take calcium/vitamin D supplements and discuss lifestyle changes that might benefit the patient.

CONTRAINDICATIONS

Before using this medication, the doctor should be consulted with the medical history, especially of: heart disease (e.g., chronic congestive heart failure, heart attack, angina), fluid in lungs, swelling (edema), anemia, high blood cholesterol, eye (retina) problems, bone problems (e.g., osteoporosis, osteopenia).

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